Thursday, April 19, 2018

Tetanus and malaria...ouch.


      Tetanus.  Like so many things here I’ve read about it, but never treated it.  Malaria, filariasis, typhoid fever, PJP pneumonia, and now tetanus.  I was off duty when a 12 year old girl was admitted to the children’s ward for prolonged muscle spasms/contraction, and a positive malaria test.  It’s important to note that these aren’t muscle spasms like one might experience with a “Charlie horse” or dehydration; these muscle spasms are about as tight as possible, and the muscles stay contracted for hours at a time.  The girl couldn’t open her mouth due to “lock jaw,” which is a prolonged contraction of the chewing muscles.  She couldn’t bend her arms or legs.  Most painful of all she had a condition called opisthotonus.  This is when the muscles around the spine become so contracted that the person can keep everything but their head and ankles off the floor if laying on their back.  I think a picture from Dr. Google might help here:

Image result for opisthotonus


(Dr Google warned me that this might be copy-written, but since the website is displayed, I am quoting the source).  So imagine maintaining this position for hours at a time, and just when you start to relax something (light, sound, etc) causes your muscles to spasm again. 
                So how do you treat tetanus?  Well, you give tons of muscle relaxers like diazepam, pain medicine like morphine, tetanus toxoid if available to try and counteract some of the tetanus poison that the bacteria has released, and antibiotics to kill off the tetanus bacteria remaining (Clostridium tetani for the nerds in the audience).  The admitting house officer had ordered the correct medications, but as is not uncommon our pharmacy was out of them (metronidazole preferably, or aqueous penicillin if metro is not available).  At least we had lots of diazepam and morphine, which I increased rather rapidly trying to relieve her pain while at the same time not killing her (which would have made the whole hospital visit kind of counter-productive).  I mentioned earlier that she also had malaria (lucky girl), and fortunately one of the medications to treat severe malaria is Clindamycin (along with Artemesin, which we were also out of, but Arthemeter was available so close enough).  But wait!  Clindamycin also treat Clostridium difficile and Clonstridium perferingens.  Could it be that it also treats tetanus?  Hooray!  That actually is among the acceptable medications.  It costs more per dose than most people make in a week, but when that’s your only option you go with it.  We only had to give that for a couple of days as we got more metronidazole.  Luckily her fever reduced, and gradually the spasms became less and less.  We were able to transition her over to oral diazepam and tramadol, and when she went home she was just having the occasional mildly irritating spasms that were short lived.
                So the missionary part?  Her father only spoke French, and I discovered that the family was Muslim.  Our chaplaincy did not have any information on Christianity in French, and had I tried with my broken French it would have translated something like “you Muslim, God only one, I’m Jesus, may interest for learn more?”  Thank goodness one of our wonderful French-speaking psychiatric nurses was able to translate one of the informational tracts into French.  I wish that I could have reviewed it with him (although, again, “here paper, Muslim for Christian.  You read for learn Jesus.  Maybe stop one?”). 
                All-in-all this was a great case for me to learn from.  Tetanus generally has a 30-50% mortality rate in the developing world.  Let that be yet another reason to vaccinate you children!  I thank God that she pulled through.  Just hoping I didn’t make her a Valium and opiate addict in the process.

~Bryan

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